In the span of just a few hours, two anti-Israel terrorists, high-ranking leaders in Hamas and Hezbollah, were killed.

Ismail Haniyeh and one of his bodyguards were reportedly killed by a missile in his Tehran guest house at 2 a.m. local time. The Hamas leader was in Iran for the inauguration of President Masoud Pezeshkian.

The Israeli government has not commented on the incident, which came a few hours after the targeted killing by Israel of senior Hezbollah official Fu’ad Shukar in the heart of Beirut, which was acknowledged by the Israeli military.

The Arab Gulf state, a major financial backer and political ally of Hamas, condemned the assassination, saying that the killing “and Israel’s behavior, which harms civilians, will lead to the region slipping into a cycle of chaos that will undermine the opportunities for peace.”

Iran’s terror proxy in Yemen, the Houthis, called the strike “a terrorist crime and flagrant violation.”

An Iranian source told Reuters that the “security bodies” will decide on “our response strategy” to the assassination.

Fuad Shukr, Hezbollah’s most senior military commander and a right-hand man to terror leader Hassan Nasrallah, was killed in the strike, which blew a large hole into the side of an eight-story apartment building in southern Beirut, the IDF said late Tuesday.

In a statement, the IDF said that Shukr, also known as Hajj Mohsin, was responsible for the Saturday Majdal Shams strike, as well as other deadly attacks on Israel. Since Hamas’s October 7 onslaught in southern Israel, Shukr has been managing Hezbollah’s near-daily attacks against Israel, according to the military.

He was named by the IDF several years ago as a commander of Hezbollah’s precision missile project. He is also wanted by the United States for his role in the 1983 bombing of a US Marines barracks in Beirut, with a $5 million bounty placed on his head by Washington.

The IDF said he was “responsible for the majority of Hezbollah’s most advanced weaponry, including precise-guided missiles, cruise missiles, anti-ship missiles, long-range rockets, and UAVs” and for the terror group’s “force build-up, planning, and execution of terror attacks against the State of Israel.”

Shortly after the strike, Defense Minister Yoav Gallant tweeted in English: “Hezbollah crossed the red line.” It was the first Israeli attack on the Lebanese capital since a January strike that killed Hamas’s deputy leader abroad Saleh al-Arouri.

The Israeli airstrike was precipitated by a flurry of diplomatic activity with Western nations seeking to avoid a larger escalation and urging both Israeli and Lebanese officials to practice restraint. A number of airlines canceled flights to Beirut over the past few days, and Lufthansa canceled several flights to Tel Aviv